93 TOLERANCE AND OPIOID-INDUCED HYPERALGESIA IN CLINICAL POPULATIONS
نویسندگان
چکیده
منابع مشابه
Differential Opioid Tolerance and Opioid-induced Hyperalgesia: A Clinical Reality.
Anesthesiology, V 124 • No 2 483 February 2016 O PIOIDS are highly effective analgesics and as such form the mainstay of pain management after surgery. However, they are associated with a formidable array of side effects, some of them potentially lethal. Also, the opioid signaling system has a remarkable ability—possibly unequaled by any other receptor system...
متن کاملMechanisms of opioid-induced tolerance and hyperalgesia.
Opioid tolerance and opioid-induced hyperalgesia are conditions that negatively affect pain management. Tolerance is defined as a state of adaptation in which exposure to a drug induces changes that result in a decrease of the drug's effects over time. Opioid-induced hyperalgesia occurs when prolonged administration of opioids results in a paradoxic increase in atypical pain that appears to be ...
متن کاملOpioid tolerance and hyperalgesia.
Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain. This article will review updated information from both clinical and preclinical studies regarding opioid-induced hyperalgesia, tolerance, and d...
متن کامل[Opioid-induced hyperalgesia. Pathophysiology and clinical relevance].
Opioids are the drugs of choice for the treatment of moderate to severe acute and chronic pain. However, clinical evidence suggests that opioids can elicit increased sensitivity to noxious stimuli suggesting that administration of opioids can activate both pain inhibitory and pain facilitatory systems. Acute receptor desensitization via uncoupling of the receptor from G-proteins, up-regulation ...
متن کاملMesenchymal Stem Cells Reversed Morphine Tolerance and Opioid-induced Hyperalgesia
More than 240 million opioid prescriptions are dispensed annually to treat pain in the US. The use of opioids is commonly associated with opioid tolerance (OT) and opioid-induced hyperalgesia (OIH), which limit efficacy and compromise safety. The dearth of effective way to prevent or treat OT and OIH is a major medical challenge. We hypothesized that mesenchymal stem cells (MSCs) attenuate OT a...
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ژورنال
عنوان ژورنال: European Journal of Pain Supplements
سال: 2010
ISSN: 1754-3207
DOI: 10.1016/s1754-3207(10)70098-5